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Management of the breeding and rearing facility for microbiologically and genetically regulated cynomolgus macaques. Establishment of breeding technology for efficient breeding and research of assisted reproductive technology. Research of animal models for human diseases.
Management of the breeding and rearing facility for microbiologically and genetically regulated cynomolgus macaques
We have been housed approximately 2,000 monkeys, most of which are cynomolgus macaques born in TPRC and have been maintained as specific pathogen-free (SPF) of a number of pathogenic microbes. Microbiological routine checkup has been also periodically performed in order to protect our colony from biohazard. The breeding colony is comprised of 600 cynomolgus macaques and produces yearly 250 monkeys for the mission of providing the SPF animals to national inspection of vaccines and biomedical research.

Genetic control
The cynomolgus monkeys in our colony come from the Philippines, Indonesia and Malaysia, and are maintained and managed such that monkeys from different habitat areas are not mated. Breeding is conducted to maintain hereditary differences within a certain constant deviation, and thus to avoid inbreeding. In addition, breeding is also conducted to produce siblings and to maintain the family lineage. By this genetic control, the monkeys in our colony enable biological analysis for discovering differences between habitat areas. In medical science these monkeys enable the analysis of various hereditary diseases. Consequently, our colony is known worldwide.
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Management of biosafety
Because of their close phylogenetic relationship between human and monkey, both may share susceptibility to biohazardous microbes and may cause zoonosis. For example, Mycobacterium tuberculosis is pathogenic to both human and monkey, while B virus occasionally causes critical diseases to human but not monkey; on the other hand, simian varicella virus infection to macaques may result in lethal disease. All the monkeys in our facility have already been confirmed to be free from these life-threatened pathogens.
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Lineage management
Each monkey in the colony is medically inspected in detail daily. The health condition, breeding conditions, clinical treatment, and experimental procedures, etc., are recorded on a computer. The breeding data can therefore readily be analyzed, such as the lineage administrative information. For example, the lineage of hereditary disorders such as yellow spotted degeneration, hyperlipemia, and mental illness can be analyzed. This figure shows the family pedigree related to yellow spotted degeneration. Analysis of the genetic code is possible by studying individual whose lineage is managed.
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Aging Farm
The animal colony consist of aged primates is one of the most effective research resource for investigating pathogenesis of infectious diseases, cognitive impairment, and lifestyle-related diseases, and also useful for developing therapy for them. We call this animal colony as “aging farm”, and we enthusiastically manage and maintain the farm for research using aged monkeys. The photograph (below, left) shows a 36-year-old cynomolgus monkey in our aging farm. The other photograph (below, right) shows our originally established maze learning instrument; monkeys move feed by using their fingers to goal, and they can eat them. Such instrument can enable us to investigate behavioral analyses of aged monkeys.
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